Fallout: New Vegas

Fallout: New Vegas is an upcoming role-playing video game in the Fallout series, currently in development by Obsidian Entertainment (many employees of which worked for Black Isle Studios on Fallout and Fallout 2) and has been scheduled for release on October 19, 2010, in North America, and October 22, 2010, in Europe.
Fallout: New Vegas is not a direct sequel to Fallout 3. The game offers a similar role-playing experience as Fallout 3 and events are set three years later. However, reportedly, no characters from the previous game will appear.

The game places the player in the role of a courier. The courier, while delivering a package to a town called Primm with a platinum poker chip and NCR war documents, is found half dead in a shallow grave after being shot in the head by Benny, the leader of a crime family called the Geckos, and left for dead. The Courier is rescued by a robot named Victor who brings the courier to Doc Mitchel who treats the courier's injuries. Thereafter the player enters into character creation (defining skills and attributes, name, gender, age and appearance) before investigating the assassination attempt, recovering the stolen package, and exploring the world.